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There is a need to reassess this important class of drugs, and to reconcile the discordance between the historic success of covalent drugs and the reluctance of most drug discovery teams to include them in their armamentarium

Johnston JN, Thacker JS, Desjardins C, Kulyk BD, Romay-Tallon R, Kalynchuk LE, et al

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10.3390/ijms20236087 26 BazzicalupoM.CornaraL.BurlandoB.CasciniA.DenaroM.SmeriglioA.et al (2021)

TET2 is broadly expressed in hematopoietic (blood) cells and some other tissues, but especially in hematopoietic stem cells (HSCs), ensuring a major role in blood cell differentiation (Solary et al