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As the N and Ctermini usually display a relatively high degree of flexibility, and comprise only one third of the amino acid content compared with the cytoplasmic domains, we suggest that the most prominent hydrophilic density observed in the 3D map faces the cytosolic side of the membrane

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Leliaert, E.J

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The underlying mechanisms driving the neurodegenerative process in glaucoma include ischemia/hypoxia, mitochondrial dysfunction, oxidative stress and neuroinflammation

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Huang H, Kong L, Luan S, Qi C, Wu F

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The binding of Nrf2 to AREs is controlled by the small Maf proteins (MafG, MafK, and MafF), which form heterodimers with Nrf2, effective in the activation of AREs, but at the same time, Maf proteins can homodimerize with each other, preventing the activation of AREs by Nrf2 [193,194]

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