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For example, in Drosophila intestinal stem cells (ISCs), loss of cnc (a homolog of mammalian Nrf2) leads to excessive ROS accumulation, which accelerates over-proliferation of ISCs and age-related degeneration of the intestinal epithelium 69

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Simultaneous imaging of axonal boutons and their partnering spines in the context of behavioral manipulation will provide abundant information to address this question

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In cellular models of ALS the RNA processing gets severely impaired upon oxidative stress, in turn causing the mis-localization of TDP-43 and FUS ( Another major factor contributing to the pathophysiological mechanisms in ALS is excitotoxicity, triggered by excessive postsynaptic glutamate receptor stimulation