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Description
Fibrates are derivatives of fabric acid whose mechanism of action relies on the activation of the nuclear receptor peroxisome proliferator-activated receptors alpha (PPAR), which leads to several changes in metabolism, including a reduction in the production of APOC3 (the already mentioned physiological inhibitor LPL) and an increase in the expression of LPL, both alterations leading to a significant rise in LPL activity and a reduction in TG level in bloodstream [9,175-177]
Clearly, high grades of evidence 19 could not be provided based on case reports and retrospective studies describing a few, rare and scattered paediatric patients with hyperammonaemia requiring dialysis
10.1038/s41598-021-99568-3 85 ZhuL.WangQ.ZhangL.FangZ.ZhaoF.LvZ.et al (2010)
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Nat Rev Immunol (2023), 12
