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Chain-breaking antioxidants such as vitamins E and C halt the process of radical formation by stabilizing free radical molecules so that the chain-like process of radical formation is arrested

For example, if phenytoin levels are therapeutic, the administration of a drug competing for protein binding could double the free phenytoin level (if protein binding decreases from 90% to 80%)

Cysteine is required for the synthesis of GSH, an important antioxidant which regulates redox sensitive pathways including mTORC1 signaling and ISR 26,27

Besides, TMAO is excreted mainly through the kidney, 96% of which is eliminated in urine by 24 h (Taesuwan et al., 2017)

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[DOI] [PubMed] [Google Scholar] 112.Ehninger D., Silva A.J