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Administration Routes: Intramuscular vs

Metabolic profiling of alternative NAD biosynthetic routes in mouse tissues

Rotate sites systematically (abdomen at least 2 inches from navel, thighs, upper arms) to avoid lipohypertrophy [8]

A: Add sterile bacteriostatic water, sterile saline, or PBS slowly and directly onto the lyophilised powder

Available in 5mg or 50mg vials (50mg total or 500mg total per 10 vials)

However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]