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Description
152 Observational evidence from a study in 307 subjects with a history of retinal vein thrombosis found taking 100 mg pycnogenol daily was associated with the lowest incidence of repeat retinal vein thrombosis compared with aspirin, ticlopidine, sulodexide, or no medication, and was the only treatment associated with reduction in edema
they aren't interchangeable

I was amazed to feel significantly better by the very next day

[DOI] [PubMed] [Google Scholar] 266.Prez-Torres A, Vera-Aguilera J, Hernaiz-Leonardo JC, Moreno-Aguilera E, Monteverde-Suarez D, Vera-Aguilera C, et al

Many people who suffer from low energy, fatigue, and headaches turn to B12 supplements, often in the form of daily pills

Yes, by staying hydrated, eating a light meal beforehand, and managing stress
