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2), we found that almost all complications share a common mechanism (NRF2) for regulating ferroptosis, but due to the inherent characteristics of the tissues, they also have relatively unique regulatory methods

10.1093/ajcn/79.5.727 88 MarJ

Clancy, R

This peripheral restriction is fundamentally different from compounds like Semaglutide (a GLP-1 agonist that acts centrally to reduce appetite) or ghrelin-modulating agents that directly influence hunger hormones

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