acetaminophen glutathione depletion mechanism Silymarin prevents acetaminophen-induced hepatotoxicity via up-regulation of the conjugation capacity in mice The Metabolism of Acetaminophen and

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Antioxidants 12 (4), 968

Kinetic assays showed that rifampicin significantly induced CYP3A4 activity in iHLOs over three days, while ketoconazole consistently suppressed CYP3A4 activity over the same period (Fig

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