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2.4 Correlation between GPX4 downregulation and OA severity Extensive clinical pathological analyses and rigorously controlled animal model studies collectively reveal a clear pattern: the protein expression level or biological activity of GPX4 typically shows a significant negative correlation with the severity of OA lesions

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As a specific scavenger of superoxide anion free radicals and a high-quality regulator of various functions of the human body, it has been widely used in food production applications [79]

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By maintaining high levels of both NAD+ and glutathione, you are essentially giving your body the tools to perform "routine maintenance" more effectively

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According to the experiment, when MEG3 is silenced, the number of granule cells increases, and apoptosis of granule cells is inhibited [139]

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It has been hypothesized that centenarians tend to have higher GSH levels due to multiple factors such as different genetic predisposition, life habits (e.g., intake of vitamins A, C, and E), and fewer chronic diseases (e.g., cancer) (Mecocci et al., 2000, Paolisso et al., 1998)

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