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It is currently MHRA and NICE approved for treating bladder pain (interstitial cystitis of the bladder) , so it can be repurposed as an osteoarthritis treatment

Beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia in patients with advanced lung cancer: An open-label, multicentre, randomised, controlled phase II trial (NOURISH) BMC Cancer

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Since glucocorticoids are known to mediate inhibition of NF-kB (beneficially modulated by certain antioxidants such as thiols), adjunctive therapy with an effective thiol donor (e.g., NAC or SAMe) and vitamin E may optimize control of inflammatory mediator release and cell response as compared to pure immunomodulatory treatment or therapy limited to antioxidants