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In addition to being necessary for a variety of mitochondrial processes, ions like Ca 2+ and iron can be stored within the mitochondria to preserve cellular ionic equilibrium

Indeed, most class II chelatases that insert metals into sirohydrochlorin appear to lack metal specificity and hence these enzymes will insert Fe(II), Ni(II) and Co(II) into the tetrapyrrole substrate [163]

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(2009), showing very encouraging results on the amelioration of several fibromyalgia ACR (American College of Rheumatology) criteria and on the chronic fatigue symptom

doi: 10.1159/000362677

Eelen G, de Zeeuw P, Treps L, Harjes U, Wong BW, Carmeliet P