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These data suggest that structure and sequence determine which lysine acetylation sites are accessible for enzymatic deacetylation, supporting earlier findings of our laboratory 64

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These include TRPC channels (e.g., TRPC6 in humans ( 2+ influx and membrane vesiculation ( 2+ activates Ca 2+ -sensitive Gardos channels (KCa3.1, encoded by KCNN4), resulting in K + efflux, membrane hyperpolarization, Cl loss, and subsequent osmotic cell shrinkage (Rapetti-Mauss et al., 2017)

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Mitochondrial problems were present as early as P15 (postnatal day 15) 17 , and they were also observed in the upper motor neurons (UMNs) of a broad spectrum of ALS patients with TDP-43 pathology 16

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