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Moreover, we expected to confirm the targets and action mechanisms using in vitro and in vivo experiments

10.1074/jbc.M309660200 76

To date, there is only one approved medication available to treat ALS, namely riluzole, which only increases survival by 3 months (Bensimon et al., Energy metabolism disturbances in ALS There are many lines of evidence for the role of disturbed energy metabolism in ALS pathogenesis

Effect of glucomannan on obese patients: a clinical study

doi:10.1007/s10753-019-01126-7

A different randomized, double-blind, placebo-controlled clinical trial demonstrated that daily oral administration of equal-lower doses (5 g/day) of l-ARG for a shorter period (6 weeks) compared to the current study induced a significant subjective improvement of penile erectile function, as assessed through standardized OLeary questionnaire for ED, although without a significant improvement of penile vascular parameters assessed by basal PDU, in 29 middle-aged/elderly men affected by organic ED of mixed etiology and unknown severity, therefore reporting, in line with the results of the current study, a discrepancy between subjective and objective improvement in erectile function [28]