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Available data show an increased risk of major congenital malformations and neurodevelopmental disorders in both Divalproex sodium/Valproate/Valproic acid monotherapy and polytherapy (concomitantly with other antiepileptic drugs) compared to the population not exposed to Divalproex sodium/Valproate/Valproic acid

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High caffeine intake (more than 500 mg or about five cups of coffee per day) reduces the chance of pregnancy by an estimated 45%

Mondul AM, Moore SC, Weinstein SJ, Karoly ED, Sampson JN, Albanes D (2015) Metabolomic analysis of prostate cancer risk in a prospective cohort: the alpha-tocolpherol, beta-carotene cancer prevention (ATBC) study