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P.BarisanoG.SweeneyM

Chemosphere 298, 134221

The ROS scavenging property of Sp was also replicated in the Drosophila models knocked-down for essential antioxidant enzymes catalase and glutathione peroxidase, where neuronal cells of 15 days AEL flies genetically expressing a redox biosensor, roGFP showed reduced fluorescence under Sp treatment (Fig

The first reaction of AMS metabolism, which converts 2-AMS to 2-aminomuconate (2-AM) is catalyzed by the enzyme encoded by the ALDH8A1 (aldehyde dehydrogenase 8 family member 1) gene

Inflammasomes, formed in the cytosol in response to pathogen- or damage-associated molecular patterns (PAMPs/DAMPs), activate pro-caspase-1, which processes IL-1 and IL-18 into their active forms and coordinates their secretion (9)

Time-course studies demonstrate sustained receptor activation over extended incubation periods