why injections for depleted vitamin b12 B12: How Frequently Should I Get It? How Long Does It Take
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With the shot, the B12 is absorbed rapidly thanks to the blood supply in the muscle and you should experience benefits right away

Interestingly, the immunological phenomenon of original antigenic sin, where immune responses to subsequent similar but nonidentical antigens are dominated by less effective cross-reactive immunity rather than generating de novo highly specific and effective immunity, has been described for influenza

PLoS One 8: e81155 pmid:24312270 21

It can also be administered into the vein, but the majority is likely to be absorbed through urine
