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Indeed, an intact VN appears necessary for certain antisteatotic reflexes: leptin's ability to reduce liver fat depends on vagal signaling to stimulate triglyceride export from the liver, further highlighting the vagal role in lipid metabolism (Metz et al

Additionally, 15 randomized controlled trials on SQJTG showed no liver or kidney damage, indicating it significantly reduces hypoglycemia risk and has efficacy and safety as T2DM adjuvant therapy [171]

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Individualized program design, including adjustments to intensity and duration, is crucial for optimizing outcomes

org/ 10.1371/j ournal .pone.0066418 65