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Cycling Considerations Although 5-Amino-1MQ and AOD-9604 can be stacked, their optimal cycle lengths differ based on their mechanisms and tolerability profiles

In contrast, the 2,3-diamino substitution in the 1MQ scaffold (2,3-diamino-1MQ) displayed high passive permeability (Table 1), but moderate bi-directional active transport with moderate efflux ratio (Table 2)