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A phase 3, multicenter, randomized, double-blind, placebo-controlled study of rilotumumab in combination with cisplatin and capecitabine (CX) as first-line therapy for Asian patients (pts) with advanced MET-positive gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The RILOMET-2 trial

Introduction Brain-derived neurotrophic factor (BDNF) Receptors of BDNF and signalling pathways BDNF has neuroprotective effect in experimental stroke models Applications and challenges Conclusion Hypoxia-ischemia (H/I) brain injury results in various degrees of damage to the body, and the immature brain is particularly fragile to oxygen deprivation, termed hypoxia-ischemia brain damage (HIBD), which can be caused by extreme prematurity or perinatal asphyxia

[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Horimoto Y., Polanska U.M., Takahashi Y., Orimo A

Once you establish these factors, dosing becomes much clearer

Reduces side effects

These symptoms are usually short-lived and naturally dissipate without intervention