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The overexpression of arginine methyltransferase 5 (PRMT5) in solid and hematological tumors leads to the elevation of the methylation level of arginine residues on functionally related proteins in tumor cells, which affects cell cycle regulation, mRNA splicing, cell differentiation, signal transduction, and other physiological processes

Upregulation of periostin prevents high glucose-induced mitochondrial apoptosis in human umbilical vein endothelial cells via activation of Nrf2/HO-1 signaling

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Therefore, the authors investigated their specific binding modes to OR separately

Peptic ulcers, varices in the esophagus, and upper GI cancers are common causes of melena
