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This process enhances innate immunity through the production of antimicrobial peptides by macrophages [43, 44] while inhibiting dendritic cell maturation and the release of proinflammatory cytokines and promoting a state of tolerance [39, 45]

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Many preclinical studies have demonstrated that the expression of key enzymes for GSH synthesis (GCL, SLC7A11, GS) and GSSG reduction-related enzymes (G6PD, NADPH, and GR) is downregulated in myocardium exposed to pathological factors [40, 43,44,45,46,47,48,49,50]

[DOI] [PMC free article] [PubMed] [Google Scholar] 59.Rahman I., Biswas S.K., Jimenez L.A., Torres M., Forman H.J

doi: 10.1155/2012/161837 80 LaurentiGTennantDA

BPC 157 has not been approved for human therapeutic use by major regulatory bodies like the FDA or the U.S