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The intestinal epithelium together with gut-associated lymphoid tissue and the neuroendocrine network work at regulating transport of environmental or dietary antigens from the intestinal lumen into the sub-mucosa.[2] Dysregulation of the mucosal barrier leads to leakiness of antigens and other macromolecules into the host to initiate systemic inflammation and immune activation which in turn influences tolerance and immunity

However, amid all the buzz, there is also confusion

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These multi-agent compounds are used in chronic wound management, post-surgical care, and pressure injury treatment where commercial wound care products offer insufficient therapeutic breadth