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Chronic pain involves persistent nociceptor and microglial overactivation, which leads to electron transport chain (ETC) dysfunction in neuronal mitochondria and excessive production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)
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Front Physiol 12:680544 Deng F, Zhao BC, Yang X et al (2021) The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis

The consequence of penetrating epithelial cells is the initiation of the ionization process where NSAIDs do not dissolve in fats, thus remaining present in these cells

& Siegers, C
