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pmid:20942504

An important contributor to leptin resistance is changes to leptin receptor signalling, particularly in the arcuate nucleus

Basic and Applied Histochemistry 24:372, 1980

40 Therefore, the interaction between antioxidants and iNOS/COX-2 presents a possible target for inflammation management

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These fluctuations increase oxidative stress, creating more cellular noise that glutathione must manage. At the same time, the bodys ability to produce glutathione is already declining with age