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Description

By exploiting a cell-penetrating peptide capable of inhibiting MRE11 Kla, Chen and collaborators showed that this approach restored HR activity and increased the sensitivity of CRC cells to cisplatin and PARP inhibitors [97]

Tumor cells also interact with the ECM and cause changes that result in the alteration of its physical properties, increasing its density and stiffness (115)

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Metabolic Research Applications In published research, MOTS-c is most frequently studied in connection with cellular energy metabolism, exercise-response models, and age-related metabolic decline a research area explored further in our guide to peptides for longevity research