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[23] Activation of the PI3K pathway is currently associated with cell motility through remodeling of adhesion to the extracellular matrix as well as localized recruitment of transducers involved in cytoskeletal reorganization, such as RAC1 and PAK

Also diarrhoea, peripheral vascular thrombosis, transitory exanthema, or urticaria

[DOI] [PubMed] [Google Scholar] 200.Opie LH

ABBREVIATIONS AcBut 4-(4-acetylphenoxy)butanoic acid ADC Antibody-drug conjugate ALL Acute lymphoblastic leukemia AML Acute myeloid leukemia BTG Bacterial transglutaminase CLL Chronic lymphocytic leukemia CM Cyclization module CRC Colorectal cancer DAR Drug-antibody ratio DLBCL Diffuse large B-cell lymphoma DM1 N 2 -Deacetyl-N 2 -(3-mercapto-1-oxopropyl)maytansine DM4 N 2 -Deacetyl-N 2 -(4-mercapto-4-methyl-1-oxopentyl)maytansine DUBA Duocarmycin hydroxybenzamide azaindole FGE Formylglycine generating enzyme mc Maleimidocaproyl mcc Maleimidomethyl cyclohexane-1-carboxylate, linked to cysteine of mAb MCC Maleimidomethyl cyclohexane-1-carboxylate, linked to thiol of cytotoxin MDR Multidrug resistance MM Multiple myeloma MMAE Monomethyl auristatin E MMAF Monomethyl auristatin F NHL Non-Hodgkin lymphoma NHS N-hydroxy succinimide nnAA Non-natural amino acid NSCLC Non small-cell lung carcinoma PABC Para-aminobenzyloxycarbonyl PBD Pyrrolo[2,1-c][1,4]benzodiazepine RCC Renal cell carcinoma SC Squamous cell SCCHN Squamous cell carcinoma of the head and neck SPDB N-succinimidyl-4-(2-pyridyldithio)butanoate sulfo-SPDB N-succinimidyl-4-(2-pyridyldithio)-2-sulfo butanoate va Valine-alanine vc Valine-citrulline References 1.Schwartz RS