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DErcole AJ, Stiles AD, Underwood LE

Administering at a similar time each night helps in aligning with the bodys circadian rhythm and supports sleep-wake cycle stability

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In an in vivo study, the aqueous fraction of Paullinia cupana seeds was repeatedly administered to rats who were then placed in a T-maze, a model of generalized anxiety and panic disorders, and the guarana was shown to have anxiolytic and panicolytic effects [242]