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In assumption 3, IVs can only affect the outcome through exposure, meaning no gene pleiotropy (64)
Therefore, an infusion is needed instead

Wollina U, Goldman A, Heinig B
10.3390/ph12020093 Pharmaceuticals 95 MathysH.Davila-VelderrainJ.PengZ.GaoF.MohammadiS.YoungJ
Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM