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Sequences within apolipoprotein(a) Kringle IV types 6-8 bind directly to low-density lipoprotein and mediate noncovalent association of apolipoprotein(a) with apolipoprotein B-100

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BMC Genomics 24 , 341 (2023)

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however, while we cannot formally rule out this possibility, the effects of these drugs on Cdk5-associated survival are likely occurring due to the effects of the drug in the brain, since this is the tissue where Cdk5 activity is restricted and that is sensitive to Cdk5 pathology