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A phase II randomized controlled trial demonstrated that deferiprone, an iron chelator, significantly reduced iron accumulation in the substantia nigra accompanied by measurable improvements in motor function assessed by UPDRS [259]

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The in silico results confirmed the in vivo and in vitro findings and indicated promising molecular interactions through 1JIJ, 1HD2, 2XCT, and 1CX2 pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] McQuaid C

[DOI] [PMC free article] [PubMed] [Google Scholar] [18].Prasad A, Andrews NP, Padder FA, Husain M, Quyyumi AA