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If fatigue continues, a clinician may evaluate anemia, thyroid disease, sleep problems, medication effects, mood concerns, or other causes

Caution is recommended in individuals with seizure disorders, as increased frequency or severity of seizures has been reported during therapy

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Once diagnosed, B12 deficiency is typically straightforward to treat , and many people notice a difference in their skin within weeks

If low B12 explains fatigue and weight loss, replacement will likely restore health and weight

Wrobel, L., Trojanowska, A., Sztolsztener, M