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Isochorismate is then the substrate for PHYLLO, 42 a trifunctional enzyme with 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-2-carboxylate (SEPHCHC) synthase, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-2-carboxylate (SHCHC) synthase and OSB synthase domains (reactions 24, Figure 2)

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Similarly, this compound inhibits Th17 and Th1 cell differentiation by reducing STAT3 and STAT4 phosphorylation, respectively, and suppresses mTORC1 pathway activity independently of PI3K/AKT and ERK signaling in DSS-induced colitis mice [495]

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The simultaneous exposure to hyperglycaemia and macrophages can increase the migratory potential of PDAC cells through the epithelial-to-mesenchymal transition (EMT) [212]