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Results of experimental and clinical investigations demonstrated the effects of the synthetic peptide on the course of retinitis pigmentosa, a degenerative process of the retina resulting from disturbed metabolism of specific proteins in the pigmented epithelium and other retinal layers [38]

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85 Moreover, the systems pharmacology approaches integrating the biology of anti-VEGF resistance with the prognostic, predictive, pharmacodynamic and surrogate biomarkers coupled with computational imaging techniques such as dynamic contrast-enhanced magnetic resonance imaging and other imaging tools monitoring the vessel permeability, integrity and tumor perfusion might be helpful in ameliorating the drug resistance and optimizing the performance of anti-angiogenic drugs 86

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