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This is a functional marker of glutathione status

Due to the elicited increase in plasma bilirubin, albumin administration to reduce bilirubin-induced neurological damage invalidates the use of plasma total bilirubin as an indicator of the overall risk of bilirubin neurotoxicity (Vodret et al., 2015)

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In vivo experiments further demonstrated that Irisin-loaded bone marrow mesenchymal stem cell-derived exosomes significantly inhibited activation of the YAP/EGR1/ACSL4 signaling pathway in the brains of middle cerebral artery occlusion (MCAO) mice, suppressed ferroptosis and lipid peroxidation, thereby mitigating ischemic brain injury ( In vitro experiments further confirmed that FGF21 protected HT22 cells from OGD/R-induced oxidative stress and ferroptosis, thereby attenuating neuronal injury ( In vivo experiments confirmed that 4 weeks of aerobic training significantly increased the expression of exosome miR-484 in the skeletal muscle of ischemic stroke rats

Oxidative stress and mitochondrial dysfunction Oxidative stress refers to the imbalance of two opposite and antagonistic forces, production of ROS and antioxidants, wherein the damaging effects of ROS is more powerful compared to the compensatory effect of antioxidants in the cells