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For instance, randomized controlled trial using a synbiotic formulation containing Lacticaseibacillus rhamnosus, Lactiplantibacillus plantarum, Bifidobacterium lactis, Bifidobacterium longum , fructo-oligosaccharides, and zinc showed significant reductions in post-exertional malaise and increased brain metabolites in post-COVID-19 CFS patients (Varesi et al., 2021