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In veterinary contexts, a supplement containing S-acetyl-glutathione has been studied in dogs with liver disease, suggesting that form and formulation choices can be clinically relevant

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The intracellular concentrations of vitamin B12 can be inferred through the total plasma concentration of homocysteine, which can be converted to methionine through an enzymatic reaction that uses 5-methyltetrahydrofolate as the methyl donor group

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Emir et al., 2011)