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These problems also occur with normal B12 levels B12 levels can be altered with a variety of medications including antibiotics, anticonvulsants, birth control pills, cholesterol lowering drugs, and high blood pressure medicine

Approximately 50% of patients with cancer have a p53 gene mutation that leads to the inactivation of wild-type p53 (64)

Cancer Res 1997

[DOI] [PubMed] [Google Scholar] [173].Phielix E, Meex R, Moonen-Kornips E, Hesselink MK, Schrauwen P

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We next investigated the role of MKRN1 in p53 stabilization upon DNA damage, and found that the p53 stabilization induced by the DNA-damaging agent cisplatin was attenuated in both MKRN1 KO HT1080 cells and MKRN1 knockdown HT1080 cells (Fig