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The discontinuation was driven by (Bergam, 2025) (Figure 2): the availability of newer, safer & more accurate alternative testing for MG including electrophysiological & antibody tests, as well as safety concerns (bradycardia & respiratory complications) limited diagnostic reliability (with both false-positive and false-negative results) The decision to remove edrophonium as an available (alternative) diagnostic test has been challenged (Keritam et al, 2026)

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We have previously described our approach to untargeted metabolomics, which, in contrast to previous research models of pooled cases and controls, instead takes an n of 1 approach that we believe efficiently bridges both clinical and research spheres (175, 176)

Zhu LY, Nie L, Zhu G, Xiang LX, Shao JZ (2013) Advances in research of fish immune relevant genes: a comparative overview of innate and adaptive immunity in teleosts