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Phentermine failures can occur because the appetite suppression was insufficient, because tolerance developed too quickly, or because the patient eating patterns were driven by factors other than hunger (emotional eating, habit, environment)

Exercise and Polycystic Ovary Syndrome

[PubMed 3092648] 1028

it may be that your body lacks the B12 needed to utilise the energy your thyroid is trying to provide

This is particularly relevant in the context of BH3 mimetics, as they display limited anticancer activity when used in monotherapy settings 81

[DOI] [PMC free article] [PubMed] [Google Scholar] 318.Jagtap A.G., Patil P.B