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MEK1/2 inhibitors suppress pathological -synuclein and neurotoxicity in cell models and a humanized mouse model of parkinson's disease

Real-time fluorescence quantification Total RNA was extracted from kidney and intestinal tissues, as well as HK-2 and HIEC-6 cells, using the Trizol method (Invitrogen, USA)

Mayo Foundation Research Symposium

Specifically, we identified KU-57788 as a DRP1 agonist that induces excessive mitochondrial fission, which in turn activates the NRF2/SLC7A11/GSH axis as a protective response in ATC cells to mitigate its cytotoxic effects

Therefore, caspase-9 and -8 have been used to distinguish the activation of intrinsic (mitochondria-mediated) and extrinsic (receptor-mediated) cell death pathways

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