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These recurrent reductions in cerebral blood flow velocity can then precipitate ischemic changes, particularly in vulnerable border-zone areas and terminal arterial territories, especially in patients with a compromised hemodynamic reserve (e.g., those with intracranial arterial stenosis) [13]

recommended in multiple guidelines and consensuses as the first-line therapy drug for the prevention and treatment of hypokalemia

The cell-level mechanism is now confirmed by two independent labs

Halperin I
