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During adulthood, serum B12 concentrations tend to decline with age, especially in the elderly (Wahlin et al., 2002), probably arising from the gradual decrease in both gastric acidity and intrinsic factor production that occurs with aging (Asselt et al., 1998

New cells, such as neurons and red blood cells, require vitamin B12, as previously discussed

Vitamin B12 Deficiencies and Medications About 10% of the population appears to have normal serum B12, however, their bioavailable B12 is reduced

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When considering cost, factor in supplies (syringes, bacteriostatic water, alcohol swabs) and potential medical supervision fees

[NCBI Bookshelf] ncbi.nlm.nih.gov OKane M, Parretti HM, Pinkney J, et al