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Therefore, targeting microglia holds potential as a therapeutic strategy for treating cognitive disorders associated with aging, AD, and other related conditions (Lee et al., 2018

Activity of the Yap1 transcription factor in Saccharomyces cerevisiae is modulated by methylglyoxal, a metabolite derived from glycolysis

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79 In addition to the enzymes themselves, the metabolic byproducts of glycolysis, namely pyruvate and lactate, have also been shown to have a role in mediating antitumor drug resistance

thus, the phenotype is manifest fully in males whereas female heterozygotes display varying degrees of G6PD deficiency, due to alternate X-chromosome inactivation 3,4

Finally, progesterone antagonizes estrogen-mediated stimulation of oncogenes, which would otherwise promote further endometrial growth (Kirkland et al., 1992)