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As mentioned above, c-Met is aberrantly activated by gene amplification, overexpression, mutation, binding to other ligands, autocrine signaling or abnormally high HGF levels in cancer

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Eur J Pediatr 2008

The bioavailability difference between routes means the same biological effect requires a higher oral dose than injectable but the mechanistic effects themselves translate across routes because the absorbed fraction reaches systemic circulation intact enough to engage the same downstream pathways

Achieving the transcriptomic remodeling seen in the mice requires a copper load that is physiologically toxic to humans
