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Alzheimer's & Dementia: Translational Research & Clinical Interventions 2018;4:28-36

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Cardiovasc Res 62:4352, PMID: 15023551 Jourd'heuil D, Jourdheuil FL, Feelisch M (2003) Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide

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Coupling Reaction: The activated AA 2 now reacts with the amine of the solid phase N-terminal deprotected AA1 to form the peptide bond

They found that the NPs could effectively increase the penetration of drugs through the BBB, promote microglia activation, and accelerate the phagocytosis of A42 (Yang et al., 2018)