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In addition, it was found that this sdAb specifically binds to the tumor and does not spread to healthy tissue, resulting in a high tumor/normal tissue ratio

Coronal cortical slices were sectioned (300 m) with a vibrating microtome (VTS1000 Leica Microsystems) in ACSF

The chromatography resin utilizes the interactions between Ni2+ and side chains of some amino acids (mainly histidine) in the protein to separate and purify proteins with and without these amino acids and with high or low amounts of these amino acids

SNAP23, Syntaxin 4, Synaptosomal-Associated Protein 23

doi: 10.1111/exd.14395

High NO content results in the emergence of reactive NO derivatives (N 2 O 3 , ONNO , NO 2 , NO 2 ) that cause DNA damage by suppressing the activity of DNA ligase, thus increasing the number of DNA single-strand breaks