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309 Further, a meta-analysis of 13 studies found that although the motor benefits achieved via DBS of the globus pallidus internal (GPi) and STN were similar, DBS of the STN allowed for a greater reduction in medication

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Keywords: autoantibodies, cerebellar ataxia, encephalitis, GAD autoimmunity, hyperexcitability, stiff person syndrome Introduction GAD (glutamic acid decarboxylase) is a pyridoxal 5-phosphate-dependent enzyme, widely expressed within the central nervous system and pancreatic -cells, that catalyzes the conversion of the excitatory neurotransmitter l-glutamate to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)

Chronic microglial activation bathes the central nervous system in inflammatory cytokines, disrupting neurotransmitter balance and impairing cognitive functiona phenomenon commonly experienced as "brain fog." This systemic inflammation and autonomic instability create a hostile environment for normal physiological processes, forcing the body to triage its resources

Briefly, cells were bathed at RT in a HEPES-buffered salt solution (HBSS) containing (mM): 156 NaCl, 3 KCl, 2MgSO 4 , 1.25 KH 2 PO 4 , 2 CaCl 2 , 10 glucose and 10 HEPES, pH 7.35