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But Increased GH and IGF-1 Are Not a Free Upgrade Endocrine changes at this scale come with potential trade-offs: Fluid retention Glucose regulation concerns Possible long-term diseases questions linked to IGF-1 elevation (Holt, 2025

There is no officially safe maximum limit for humans

Studies have shown that high-glycemic dietsthat is, diets high in sugar and empty carbohydratescan lead to more breakouts

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