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In addition, various organelles (endoplasmic reticulum and peroxisome) and enzymes (NADPH oxidase and p450 cytochrome) also produce ROS during metabolic processes (Wang et al., 2021

Moreover, studies in PCOS patients treated with NAC (1.8 g/day for 6 weeks) have shown a decrease in receptor tyrosine kinase c-kit protein levels in follicular fluid, while the expression of growth differentiation factor-9 in mature oocytes increases, suggesting that NAC may enhance oocyte maturation and embryo quality [60]